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Biophilia Intruder has been used to treat more skin conditions

The Biophilia Intruder has an axial resolution of 30 µm. The application of this device allows the study of the epidermis at the cellular and subcellular level.

Today, the research objectives and limitations of three-dimensional NLS ultramicroscanning in dermatology have become very broad.

The following has become a reality:

- Evaluate the effectiveness of treatments in diseases characterized by cutaneous sclerosis (localized scleroderma, generalized scleroderma), edema (lipodermatosclerosis) and chronic inflammatory (psoriasis) skin diseases;

- Measuring the extent of skin tumor invasion and monitoring after surgical intervention, cryo- and laser treatment of melanoma, basaloid carcinoma, hemangioma, fibroma, seborrheic keratosis;

- Study the effects of topical and systemic drugs on the skin (corticosteroids, estradiol).

According to the method, the diagnosis of NLS ultramicroscopic scans of dermatoses must be made by comparison of the affected area with healthy skin of the contralateral homologous area.

In NLS imaging using a nonlinear sensor at 4.9 GHz frequency, normal skin is represented by three layers: epidermis, dermis, and subcutaneous tissue. Regional and age-related properties of skin thickness depend primarily on dermal thickness, which depends primarily on the collagen content within it.

It is considered that the visualization of normal epidermis is poor in NLS studies with a sensor frequency of 1.4 GHz because the actual thickness of the epidermis is 0.02 – 0.5 mm, which is the resolution limit of such systems.

The epidermis is a moderately pigmented structure (Fleindler scale of 2-3) whose pigmentation depends on the thickness of the stratum corneum and the rate of desquamation.

UHF nonlinear sensors allow the study of more of the superficial papillary layer of the dermis and the underlying reticular layer, which is characterized by a more uniform structure.

For the differential diagnosis of skin tumors such as hemangioma or melanoma, the modality of ultramicroscopic scanning with spectral entropy analysis (SEA) can be successfully applied.